In an editorial in the November issue of the American Journal of Psychiatry, naive men with schizotypal personality disorder: association with negative symptoms. Noting that there is no evidence of greater efficacy as a first, dependent patients randomised to disulfiram or placebo. 35 Kisely S, uS groups completing the intervention.
She also refers to discomfort amongst prescribers regarding involuntary phlebotomy, they develop the themes of redundancy, weekly blood tests for clozapine. They studied birth outcomes in over 300, premature death among people with mental illness. It questions how Chantix could be approved for use after testing upon only 4, and multiple other articles on related themes. Risk patients on omega, the addition of specific diagnoses for mixed anxiety and depressive states has not improved its reliability.
An article by Dempster and colleagues in the January 2013 issue of Schizophrenia Bulletin provides a less bullish review of research into epigenetic mechanisms of schizophrenia than that of Akbarian and Nestler in Neuropsychopharmacology. Schizoaffective disorder has been conceptualised as a longitudinal rather than a cross-sectional diagnosis, and delusional disorder no longer requires non-bizarre delusions, although a specifier for bizarre delusions has been added. Berlim MT, Van den Eynde F, Daskalakis ZJ.
Guha S, Rees E, Darvasi A, Ivanov D, Ikeda M, et al. The FDA announces “important revisions to the WARNINGS and PRECAUTIONS sections of the prescribing information for Chantix regarding serious neuropsychiatric symptoms experienced in patients taking Chantix.
Day-to-day associations between subjective sleep and affect in regard to future depression in a female-population based sample. 6 Dear BF, Zou J, Titov N, Lorian C, Johnston L, et al. None of the offspring developed a psychotic disorder without affective symptoms.
Kuiper et al conclude by emphasising the need to avoid reflexively associating all mood dysregulation with bipolarity, while acknowledging the clinical and systemic difficulty of doing so. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. Andreasen NC, Liu D, Ziebell S, Vora A, Ho B.
For 20 years, Cochrane has produced systematic reviews of primary research in human health care and health policy, and these are internationally recognized as the highest standard in evidence-based health care resources. The ANZJP includes diverse editorial comment on possible problems including dimensional approaches to psychiatric diagnosis and lower thresholds for diagnosis, while the American Journal includes detailed descriptions of the methodology and results of field trials establishing the reliability of the new diagnostic framework. 2012 College Address: fifty years as a psychiatrist.
They also note that social contagion should be considered as a risk factor for mood disturbance. Is treatment with corticosteroids beneficial and safe for people with pneumonia?
The 15th April issue of Biological Psychiatry includes several articles on the mechanisms and treatment of substance dependence. The DSM-5 definition of mental disorder.
A comprehensive family-based replication study of schizophrenia genes. Based on evidence that treatment of OCD often leads to incomplete symptom relief, and that glutamatergic dysfunction contributes to its pathogenesis, Bloch et al performed an open-label trial of ketamine for 10 subjects with treatment resistant OCD. The authors discuss the importance of exposure, risk and resilience, and the roles of prevention and intervention.
Because President Obama’s Affordable Care Act is likely to significantly increase Medicaid coverage for people with psychotic illness, it is also likely to significantly increase the possibility of functional FEP services across the US. UK NHS SSS 4-week Chantix 4-week stop smoking rate of 59 percent versus 50 percent for non-medication quitters. However, they note that further research is needed to exclude other biases.
Elsewhere in the BJP Schmidt and colleagues compared two outpatient psychotherapeutic treatments for anorexia nervosa and found both treatments produced similar improvements. IPS to justify its systematic implementation. Power and colleagues note their results require replication, and do not necessarily imply a causal mechanism.
Karl Jaspers: psychiatrist, philosopher, humanist. Joel Spitzer, the Internet’s leading authority on how to stop smoking cold turkey.
They conclude that despite the controversy, there is consensus that people presenting with attenuated symptoms of psychosis meet a broad definition of mental disorder with distress deserving of treatment. The authors conclude that Autism spectrum disorder, schizophrenia, and bipolar disorder share aetiologic factors. DSM-III because its diffusion into popular use had destroyed its precise meaning. The authors conclude that there was a five-fold increase in the probability of psychotic symptoms during periods of methamphetamine use, from a low baseline level during abstinence, but were not able to make causal attributions.
They point to evidence that Australian GPs continue to care for mental health issues, and that the disparity between groups has not changed over the last ten years. Dissociation in Posttraumatic Stress Disorder: Evidence from the World Mental Health Surveys. Suzy closed by asking, “has anyone else experienced this? DSM-5: Il buono, il cattivo, il brutto.
In the July issue of the American Journal of Psychiatry, Zammit and colleagues report a longitudinal birth cohort study of close to 5000 people assessed for psychotic experiences and illness at ages 12 and 18 years. Pfizer also knew that Chantix placebo group members would not be receiving anything different than received by NRT placebo group members – an inert placebo. The spread of obesity in a large social network over 32 years.
The study recommends in part that smokers “consider the use of alternative approaches to smoking cessation. 1 Christensen H, Petrie K. The risk of developing a mood episode was high until age 25, after which it became less likely.
Citer and colleagues25 describe a service addressing health needs of young people in Sydney, Australia. They found that stalkers were often mentally ill, and that psychopathology was associated with more persistent and recurrent stalking behaviour. They suggest a public health focus on contagion in social networks, and discuss emerging strategies such as encouraging greater contact with mood-enhancing peers based on social network approaches in the treatment of alcohol dependence.
The importance of social networks and the implications of contagion theory. Gitlin and colleagues advocate screening for early detection, with escalating levels of intervention involving education, problem solving, and targeted therapy for specific behaviours such as nighttime routines for sleep disturbance.
Ignore its ten worst changes. The high level of comorbidity with conduct disorder suggests a non-affective component of the disorder, and high levels of service utilisation are not consistent with a relative area of unmet need, though Copeland and colleagues concede that it is unclear how appropriate or effective the services provided are for this particular condition.
The authors speculated that reduced patient distress may have been associated with the actualisation of persecutory voices, validating patients’ experiences and allowing them a measure of control and safe experimentation with resistance to delusional ideas. In these patients decreased symptom severity after initial treatment, even in the absence of remission, was associated with improved work performance.
Papanastasiou and colleagues28 reappraise the potential of glutamatergic medications in the treatment of schizophrenia, suggested by the schizophrenia-like syndrome associated with glutamatergic antagonist medications like ketamine, with similar positive and negative symptoms and evidence of neurotoxicity in rat brains. Merrigan JM, Buysse DJ, Bird JC, Livingston EH.
They have noted other dimensions separating atypical and melancholic depression, including insomnia and early morning wakening in melancholia versus hypersomnia in atypical depression, and hyperarousal in melancholic and hypoarousal in atypical depression. Oosterbaan and colleagues report a cluster-randomised controlled trial of collaborative stepped care provided by a psychiatric nurse in a primary care setting augmenting antidepressants and CBT. The authors describe OCD as a life-long condition, with evidence of treatment efficacy with no tolerance after two years follow-up, and clear increases in relapse with discontinuation.
Pilc A, Wieronska JM, Skolnick P. RANZCP, and the secretary, CEO, and others look forward to the College congress and the College’s change in structure.
In an editorial, Kuiper et al suggest that the expanding boundaries of the bipolar diagnoses may have resulted in poor reliability and validity, weakening indications for therapy. Patel finds a possible cause of reluctance to prescribe clozapine in clinicians’ exaggerated estimate of its dangers, despite evidence that all-cause mortality is lowest in clozapine among the antipsychotics, with metabolic risks outweighed in part by reduced suicide risk. The authors note that the majority of clozapine discontinuations are due to side effects that can be managed without discontinuation.
There were no differences between the groups on transition to psychosis over the 12 months, but all groups significantly improved on negative symptoms and overall function. He muses on the apparent elimination of the syndrome shortly after the advent of the antipsychotic era in the 1950s and the inconvenient fact that antipsychotics cause catatonia in laboratory animals.
Two varenicline versus nicotine patch clinical trials occurred after this article was written. Najjar S, Pearlman DM, Alper K, Najjar A, Devinsky O. In the first part of a series, Restifo explores the nosology of depression in search of a clinically meaningful typology of depressive disorders. It is noted that the Netherlands now tests some clozapine patients four times a year.
But, clearly there’s a trade-off for those unable to avoid, move past or endure one or more of the nearly 200 potential side-effects listed on Pfizer’s “Full Prescribing Information” sheet. Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP. An editorial by Axelson15 explores the new DSM-5 diagnostic entity disruptive mood dysregulation.
So what’s the bottom line? They were reimbursed travel expenses associated with clinic visits. The full spectrum of ethical issues in dementia care: systematic qualitative review.
An association with lower birth weight was found compared with all mothers, but not when the comparator was depressed mothers not exposed to antidepressants during pregnancy. Practice-based versus telemedicine-based collaborative care for depression in rural federally qualified health centers: A pragmatic randomized comparative effectiveness trial. Warner suggested that early intervention efforts should focus on the mode of onset rather than the duration of untreated psychosis, based on evidence that slow, insidious onset of psychosis is associated with worse illness requiring more intensive intervention. Alvarez-Jiménez M, Gleeson JFM, Bendall S, et al.
Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. We sought to identify predictors of 14-day continuous abstinence in stable outpatient smokers with SMI.
They argue for a proactive approach which promotes well-being as well as combats distress. In contrast, legislative proposals after mass shootings have banned gun possession for some people with mental illness, but efforts to limit high-capacity magazines have failed.